What is Garcinia Cambogia and its Primary Active Ingredient, HCA?
Garcinia Cambogia is a fruit, native to Southeast Asia, that contains high concentrations of HCA (hydroxycitric acid). HCA is the primary component of Garcinia that prevents new fat synthesis, causes significant appetite suppression, causes weight loss, increases energy production, stabilizes mood, promotes feelings of well-being and assists better sleep.
Appetite Suppression Studies Conducted on Garcinia Cambogia and HCA Resulting In Decreased Body Fat Percentage and Weight
Data collected from clinical trials has shown convincingly that HCA, derived from Garcinia Cambogia, can cause weight loss. In a double-blind, placebo-controlled human study conducted over 8 weeks, 60 subjects, ages 21-50, were treated with HCA. The groups whose diets were supplemented with HCA experienced a decrease in body weight and BMI by 5-6% with no adverse side effects.1 It was also observed that food intake, total cholesterol, leptin levels, low-density lipoproteins and trigycerides were significantly reduced. Other laboratory studies have shown HCA supplementation to be effective, especially in higher doses (appetite suppression and weight loss effects of HCA are dose dependent) over a period of 30 to 90 days, in reducing body fat and weight due to appetite reduction.2 3
How HCA Prevents The Synthesis Of New Fat: The Science & Clinical Research
HCA has the extraordinary ability to suppress the function of an enzyme called ATP citrate lyase, which is an enzyme necessary for the body to convert carbohydrates into stored fat.4 5 6 ATP citrate lyase is the link between the metabolism of carbohydrates (which causes energy) and the production of fatty acids.7 It is important to note that in this instance that we are not talking about the synthesis of healthy essential fatty acids like omega-3s. Essential fatty acids are defined as fatty acids that humans must ingest for good health but cannot synthesize them.8 Rather, supplementing the diet with high concentrations of HCA like that in Evergenics Premium Garcinia Cambogia, disables the body’s ability to create new unwanted fat stores from carbohydrates, by nullifying the enzyme ATP citrate lyase, the fatty acid synthesis catalyst.9
Increased Energy and Additional Appetite Reduction: HCA’s Influence On Leptin Levels
In the human study in which subjects lost 5-6% body fat, researchers noted that HCA caused a significant drop in serum leptin levels.10 Leptin is synthesized by fat cells and acts primarily in areas of the brain having to do with food intake inhibition and energy expenditure. When leptin levels rise, leptin resistance develops, which results in leptin losing its ability to inhibit appetite and increase energy expenditure. By reducing leptin and preventing leptin resistance, HCA assists appetite control and increased energy.11 12
How HCA Stabilizes Mood, Elevates Feelings of Well-Being, Improves Sleep and Controls Appetite By Influencing Serotonin: The Science & Clinical Research
As we presented earlier, HCA suppresses ATP citrate lyase in performing its role of beginning the fat synthesis process.13 As a result of this metabolic intervention, glycogen synthesis increases in the liver causing a signal to the brain to stimulate the increase of serotonin.14 Serotonin regulates mood, sleep and appetite control.15 16 17 By increasing serotonin production naturally, the HCA in Garcinia Cambogia promotes appetite suppression, feelings of well-being and mood stability.
Why Choose Evergenics Premium Garcinia Cambogia Today?
Evergenics Premium Garcinia Cambogia is an ultra pure and incredibly potent formulation. And like all Evergenics products, you can try it 100% risk-free, today. If Evergenics Premium Cambogia does not 100% completely meet your expectations, we’ll give you a full refund, hassle-free, no questions asked!
Ingredients listed on product labels may look similar, but quality and effectiveness can vary drastically between products. Where the ingredients originate, which part of the plant (for instance, root, leaf, or rind) is used and how it is processed all have a significant impact on the results you get. Formulas processed in poor facilities with poor ingredients can not only be ineffectual, they can be impure and unsafe. By using only the highest quality ingredients and processing them in a state-of-the-art facility registered with the United States FDA, we know we are providing you with the most effective Garcinia Cambogia formula you can buy, anywhere.
2. Michael Shara, Sunny E. Ohia, Taharat Yasmin, Andrea Zardetto-Smith, Anthony Kmcaid, Manashr Bagchr, Archana Chatterjee, Debasis Bagchi and Sidney J. Stohs: Dose- and time- dependent effects of a novel (-)- hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Molecular and Cellular Biochemistry 254: 339 -346, 2003
3. Sullivan Ann C., Joseph Triscari, James G. Hamilton and 0 Neal Miller (1974b) Effect of (-)-hydroxycitrate upon the accumulation of lipid in the rat: II. Lipids 9,2 (1974) 129-134
4. Ma, Zhengping, Ching-Hsuen Chu, and Dong Cheng. “A Novel Direct Homogeneous Assay for ATP Citrate Lyase.” US National Library of Medicine, National Institutes of Health. The American Society for Biochemistry and Molecular Biology, 2009. Web. 19 Jan. 2016. www.ncbi.nlm.nih.gov/pmc/articles/PMC2739766
5. Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS (March 1992). “Cloning and expression of a human ATP-citrate lyase cDNA”. Eur. J. Biochem. 204 (2): 491–499. doi:10.1111/j.1432-1033.1992.tb16659.x. PMID 1371749
6. Shara, M. “Physico-chemical Properties of a Novel (-)-hydroxycitric Acid Extract and Its Effect on Body Weight.” National Center for Biotechnology Information. U.S. National Library of Medicine, 2004. Web. 19 Jan. 2016. www.ncbi.nlm.nih.gov/pubmed/15228099
7. Sun T, Hayakawa K, Bateman KS, Fraser ME (August 2010). “Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography”. J. Biol. Chem. 285 (35): 27418–27428. doi:10.1074/jbc.M109.078667. PMC 2930740. PMID 20558738
8. Robert S. Goodhart and Maurice E. Shils (1980). Modern Nutrition in Health and Disease (6th ed.). Philadelphia: Lea and Febinger. pp. 134–138. ISBN 0-8121-0645-8
9. Shara, M. “Physico-chemical Properties of a Novel (-)-hydroxycitric Acid Extract and Its Effect on Body Weight.” National Center for Biotechnology Information. U.S. National Library of Medicine, 2004. Web. 19 Jan. 2016. www.ncbi.nlm.nih.gov/pubmed/15228099
13. Sun T, Hayakawa K, Bateman KS, Fraser ME (August 2010). “Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography”. J. Biol. Chem. 285 (35): 27418–27428. doi:10.1074/jbc.M109.078667. PMC 2930740. PMID 20558738.
14. Chuah, Ho, Beh, and Yeap. “Updates on Antiobesity Effect of Garcinia Origin (−)-HCA.” Evidence-Based Complementary and Alternative Medicine (2013): n. pag. Web
15. “Anxiety Disorders.” University of Maryland Medical Center, n.d. Web. 19 Jan. 2016.
17. Young, Simon N. “How to Increase Serotonin in the Human Brain without Drugs.” Journal of Psychiatry & Neuroscience : JPN. Canadian Medical Association, n.d. Web. 19 Jan. 2016. www.ncbi.nlm.nih.gov/pmc/articles/PMC2077351